Summary
The paper discusses the role of retinal photoreceptors in the regulation of circadian rhythms and sleep in systemic diseases, specifically focusing on diabetes and Parkinson's disease.
Categories
Diabetes and metabolic syndrome: The paper discusses how retinal photoreceptor dysfunction in diabetes can cause desynchronization between ambient light inputs and the timing of the suprachiasmatic nucleus, resulting in abnormal circadian photoentrainment and poor sleep.
Parkinson's disease: The paper explores how in Parkinson's disease, there is normal outer retinal function, however the intrinsic melanopsin-mediated PIPR for blue and green stimuli is significantly reduced, leading to sleep deficits.
Sleep and insomnia: The paper discusses how retinal photoreceptor dysfunction can lead to poor sleep in both diabetes and Parkinson's disease.
Cognitive function and memory: The paper indirectly discusses cognitive function and memory by exploring how circadian rhythms and sleep, which are crucial for cognitive function and memory, are affected in diabetes and Parkinson's disease.
Eye health: The paper focuses on the role of retinal photoreceptors, a crucial part of eye health, in the regulation of circadian rhythms and sleep in systemic diseases.
Author(s)
S Dumpala
Publication Year
2020
Related Publications
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Parkinson's disease
Sleep and insomnia
- The twoâprocess model of sleep regulation: a reappraisal
- Strange vision: ganglion cells as circadian photoreceptors
- Melanopsin-positive intrinsically photosensitive retinal ganglion cells: from form to function
- Functional and morphological differences among intrinsically photosensitive retinal ganglion cells
- The impact of light from computer monitors on melatonin levels in college students
Cognitive function and memory
- Phototransduction by retinal ganglion cells that set the circadian clock
- The twoâprocess model of sleep regulation: a reappraisal
- Strange vision: ganglion cells as circadian photoreceptors
- Information processing in the primate retina: circuitry and coding
- Melanopsin-positive intrinsically photosensitive retinal ganglion cells: from form to function
Eye health
- Phototransduction by retinal ganglion cells that set the circadian clock
- Color appearance models
- Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
- Strange vision: ganglion cells as circadian photoreceptors
- Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa