Summary
This research examines the role of the transcription factor Tbr2 in the development and survival of intrinsically photosensitive retinal ganglion cells (ipRGCs), finding it is not essential for adult ipRGC survival. The finding that ipRGCs survive optic nerve injury better than non-ipRGCs regardless of Tbr2 status has implications for understanding the resilience of the circadian photoreception pathway in disease and injury.
Key Findings
- Tbr2 is not essential for the survival of adult ipRGCs
- After optic nerve injury, ipRGCs lacking Tbr2 continue to survive at higher rates than non-ipRGCs, suggesting an intrinsic survival advantage in ipRGCs independent of Tbr2
Categories
The Science of Light: Investigates transcription factors in ipRGC development and survival, directly relevant to melanopsin-expressing photoreceptor biology.
Eye Health & Vision: Examines retinal ganglion cell maintenance and survival following optic nerve injury, with implications for retinal neuroprotection.
Author(s)
S Abed
Publication Year
2023
Related Publications
The Science of Light
- Phototransduction by retinal ganglion cells that set the circadian clock
- Color appearance models
- The mammalian circadian timing system: organization and coordination of central and peripheral clocks
- Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
- Melanopsin is required for non-image-forming photic responses in blind mice
Eye Health & Vision
- Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
- Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa
- Melanopsin and rod–cone photoreceptors play different roles in mediating pupillary light responses during exposure to continuous light in humans
- Characteristic patterns of dendritic remodeling in early-stage glaucoma: evidence from genetically identified retinal ganglion cell types
- Intrinsically photosensitive melanopsin retinal ganglion cell contributions to the pupillary light reflex and circadian rhythm