Summary
This paper investigates the effects of the drug methylprednisolone (MPL) on the circadian regulation of the core clock genes and memory impairment, concluding that MPL disrupts the central clock, leading to disrupted peripheral clocks and circadian rhythms, resulting in altered sleep and impaired hippocampal-dependent memory.
Categories
Dementia: The paper discusses memory impairment as a side effect of MPL, which is relevant to dementia as it is a disease characterized by memory loss.
Sleep and insomnia: The paper investigates how MPL disrupts sleep architecture, which is relevant to sleep and insomnia as it discusses the alteration of normal sleep patterns.
Cognitive function and memory: The paper explores how MPL leads to memory impairment, making it relevant to the category of cognitive function and memory.
Hormone regulation: The paper discusses how MPL, a synthetic glucocorticoid, disrupts the circadian regulation of the core clock genes, which is relevant to hormone regulation as glucocorticoids are a type of hormone.
Phototherapy: The paper discusses the disruption of the circadian clock, which is often regulated by light, making it relevant to phototherapy.
Author(s)
M Birnie
Publication Year
2018
Number of Citations
1
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