Summary
This doctoral thesis demonstrates that the nuclear receptor Rev-erb alpha is a pivotal component in food-entrainable circadian clock synchronization, with its deletion reducing behavioral and physiological outputs of the food clock and disrupting PER2 rhythm in the cerebellar oscillator. While not directly focused on lighting, understanding Rev-erb alpha's role in circadian regulation has implications for timed light-food interventions in chronotherapy and metabolic health design.
Key Findings
- Deletion of Rev-erb alpha reduced behavioral and physiological outputs of the food-entrainable circadian clock, indicating impaired meal-time synchronization.
- Absence of Rev-erb alpha eliminated the expected adjustment of the clock protein PER2 rhythm in the cerebellar oscillator.
- Rev-erb alpha knockout led to excessive adipose tissue accumulation, preferential fatty acid utilization, and loss of control over Lipoprotein lipase expression, linking circadian clock function to lipid metabolism.
Categories
Sleep & Circadian Health: Investigates Rev-erb alpha's role in food-entrainable circadian clock synchronization and behavioral/physiological circadian outputs.
The Science of Light: Examines nuclear receptor Rev-erb alpha as a core transcriptional repressor in circadian clock machinery, relevant to understanding entrainment mechanisms.
Author(s)
J Delezie
Publication Year
2012
Related Publications
Sleep & Circadian Health
- Phototransduction by retinal ganglion cells that set the circadian clock
- The mammalian circadian timing system: organization and coordination of central and peripheral clocks
- The two‐process model of sleep regulation: a reappraisal
- Melanopsin is required for non-image-forming photic responses in blind mice
- Strange vision: ganglion cells as circadian photoreceptors
The Science of Light
- Phototransduction by retinal ganglion cells that set the circadian clock
- Color appearance models
- The mammalian circadian timing system: organization and coordination of central and peripheral clocks
- Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
- Melanopsin is required for non-image-forming photic responses in blind mice