Summary
This pre-clinical study uses a multi-strain mouse model to identify genetic and neurobiochemical markers associated with depressive-like behavior and antidepressant (fluoxetine) response across multiple brain regions. While not directly applicable to lighting design, findings may inform understanding of biological pathways underlying depression that could complement light-based therapeutic interventions.
Key Findings
- Behavioral data collected across 30 inbred mouse strains using the tail suspension test, in both naive and fluoxetine-treated conditions
- 40 biochemical biomarkers assessed across three brain regions implicated in mood regulation, covering neuronal modulation, neurogenesis, gliogenesis, and HPA-mediated immunomodulation
- Identified genetic and neurobiochemical markers significantly correlated with depressive-like behavior and differential antidepressant treatment response across strains
Categories
Mood & Mental Wellness: Investigates biomarkers for depression diagnosis and antidepressant treatment response using a systems biology approach in mouse models.
Author(s)
CS Benton
Publication Year
2011
Related Publications
Mood & Mental Wellness
- The twoāprocess model of sleep regulation: a reappraisal
- Protecting the melatonin rhythm through circadian healthy light exposure
- Effects of artificial dawn and morning blue light on daytime cognitive performance, well-being, cortisol and melatonin levels
- Light therapy and Alzheimer's disease and related dementia: past, present, and future
- The role of daylight for humans: gaps in current knowledge