Summary
This thesis investigates the pharmacological modulation of TRPM8, a thermosensitive ion channel that serves as the primary cold sensor in mammals and is implicated in cold pain and cancer. The work has no direct relevance to lighting design, circadian health, or visual wellbeing.
Categories
The Science of Light: TRPM8 is a thermosensitive ion channel in the TRP family; while primarily a cold sensor, TRP channels share molecular families with light-sensitive channels (melanopsin/ipRGCs), making this tangentially relevant to photoreceptor biology.
Author(s)
JA Manenschijn
Publication Year
2014
Related Publications
The Science of Light
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- Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
- Melanopsin is required for non-image-forming photic responses in blind mice