Summary
This doctoral thesis examines the neuroprotective role of Müller glial cells on retinal ganglion cells (RGCs) under both healthy and pathological conditions using in vitro primary cultures from adult mammals. The findings have implications for understanding and potentially mitigating RGC death in degenerative eye diseases, where loss of RGCs leads to irreversible blindness.
Key Findings
- Müller glia demonstrated neuroprotective capacity toward RGCs in vitro under both physiological and pathological conditions.
- Heterogeneity within Müller cell populations and their responsiveness to different stimuli can influence their neuroprotective capacity and consequently affect RGC survival.
- A reliable, rapid, and simple protocol for primary culture and characterization of adult mammalian Müller cells was developed to facilitate future research.
Categories
Eye Health & Vision: Investigates neuroprotection of retinal ganglion cells (RGCs) by Müller glia, directly relevant to retinal health and conditions causing irreversible blindness such as glaucoma.
Author(s)
X Pereiro Díez
Publication Year
2019
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