Summary
This paper examines the neural and molecular mechanisms by which circadian clocks are entrained by non-photic cues, alongside photic pathways via ipRGCs projecting to the SCN through PACAP and glutamate. Understanding these mechanisms informs lighting design strategies that work in concert with behavioral and social zeitgebers to optimize circadian health.
Key Findings
- ipRGCs project to the SCN via excitatory PACAP and glutamate signaling, forming the primary photic entrainment pathway.
- ipRGCs also have dense glutamatergic projections to the intergeniculate leaflet (IGL), implicating this structure in integrating photic and non-photic entrainment signals.
Categories
Sleep & Circadian Health: Covers entrainment mechanisms including both photic and non-photic pathways relevant to circadian rhythm regulation.
The Science of Light: Discusses ipRGCs, their projections to the SCN and IGL, and the neurochemical basis of phototransduction and light-driven entrainment.
Author(s)
EJ Wams, SJ Riede, I van der Laan, T ten Bulte
Publication Year
2017
Number of Citations
12
Related Publications
Sleep & Circadian Health
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The Science of Light
- Phototransduction by retinal ganglion cells that set the circadian clock
- Color appearance models
- The mammalian circadian timing system: organization and coordination of central and peripheral clocks
- Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
- Melanopsin is required for non-image-forming photic responses in blind mice