Summary
This descriptive literature review identifies HPLC as the dominant method for measuring retinal dopamine in mice, while noting a significant gap in direct melatonin concentration measurements from retinal tissue. For lighting researchers, this highlights the methodological landscape for studying how light exposure modulates key retinal neurochemicals involved in circadian entrainment.
Key Findings
- HPLC (high performance liquid chromatography) is the most commonly used method for measuring dopamine and its metabolites from mouse retina samples.
- Dopamine research in the mouse retina substantially outnumbers melatonin research; only one article in the gathered dataset directly measured retinal melatonin concentration.
- Melatonin research in retinal studies typically focuses on metabolites or receptors rather than direct concentration measurements from retinal tissue.
Categories
The Science of Light: Reviews measurement methodologies for retinal dopamine and melatonin, both key neuromodulators in circadian photoreception and retinal light response.
Sleep & Circadian Health: Covers the role of dopamine and melatonin in circadian rhythm regulation within the retina.
Author(s)
S Anttonen, J Kokkila
Publication Year
2015
Related Publications
The Science of Light
- Phototransduction by retinal ganglion cells that set the circadian clock
- Color appearance models
- The mammalian circadian timing system: organization and coordination of central and peripheral clocks
- Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
- Melanopsin is required for non-image-forming photic responses in blind mice
Sleep & Circadian Health
- Phototransduction by retinal ganglion cells that set the circadian clock
- The mammalian circadian timing system: organization and coordination of central and peripheral clocks
- The twoāprocess model of sleep regulation: a reappraisal
- Melanopsin is required for non-image-forming photic responses in blind mice
- Strange vision: ganglion cells as circadian photoreceptors