Summary
This paper proposes cryptochrome 2 as a candidate mammalian photoreceptor involved in entraining retinal biorhythms, implicating dopaminergic circuitry and amacrine cells alongside ipRGCs in this process. For lighting designers, this suggests that retinal circadian responses may involve more complex photoreceptive mechanisms than previously appreciated, potentially informing spectral tuning strategies for circadian-effective lighting.
Key Findings
- Dopaminergic circuitry is identified as crucially involved in the light resetting of retinal biorhythms, implicating amacrine cells and upstream ipRGCs.
- Cryptochrome 2 is proposed as a candidate mammalian photoreceptor contributing to retinal circadian entrainment, extending the known photoreceptive toolkit beyond classical opsins and melanopsin.
Categories
The Science of Light: Investigates cryptochrome 2 as a candidate mammalian photoreceptor involved in light entrainment of retinal biorhythms, with implications for understanding non-visual photoreception beyond ipRGCs.
Sleep & Circadian Health: Examines the light-resetting of retinal circadian rhythms, relevant to understanding how retinal photoreception contributes to circadian entrainment.
Author(s)
J Vanderstraeten, P Gailly, EP Malkemper
Publication Year
2020
Number of Citations
14
Related Publications
The Science of Light
- Phototransduction by retinal ganglion cells that set the circadian clock
- Color appearance models
- The mammalian circadian timing system: organization and coordination of central and peripheral clocks
- Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
- Melanopsin is required for non-image-forming photic responses in blind mice
Sleep & Circadian Health
- Phototransduction by retinal ganglion cells that set the circadian clock
- The mammalian circadian timing system: organization and coordination of central and peripheral clocks
- The two‐process model of sleep regulation: a reappraisal
- Melanopsin is required for non-image-forming photic responses in blind mice
- Strange vision: ganglion cells as circadian photoreceptors