Summary
This study uses Human Organotypic Retinal Cultures (HORCs) as an experimental model to investigate retinal ganglion cell (RGC) degeneration relevant to glaucoma, exploring epigenetic regulation and mesenchymal factors as potential modulators of RGC fate. Findings from this model could inform understanding of how light-sensitive RGCs, including melanopsin-containing ipRGCs critical for circadian photoentrainment, are lost in glaucoma.
Categories
Eye Health & Vision: Investigates retinal ganglion cell degeneration in glaucoma using human organotypic retinal cultures, directly relevant to RGC health and visual system integrity.
Author(s)
M Hopes
Publication Year
2014
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