Summary
This review explores how extracellular vesicles (EVs) contribute to cellular aging and age-related diseases, including age-related macular degeneration, by transmitting senescence signals between cells. While not directly focused on lighting, understanding AMD pathology is relevant to lighting designers and healthcare providers seeking to minimize retinal stress in aging populations.
Key Findings
- Altered EV secretion is proposed as an emerging hallmark of aging, alongside established hallmarks such as genomic instability and defective proteostasis.
- EVs from senescent cells can spread senescence signals to recipient cells, potentially accelerating age-related conditions including AMD.
- EVs from young or healthy sources show potential as anti-aging or pro-rejuvenation therapeutic tools for age-related diseases.
Categories
Eye Health & Vision: The paper reviews extracellular vesicles in the context of age-related macular degeneration (AMD), an eye disease directly relevant to retinal health.
Author(s)
LFM de Carvalho Ferraz
Publication Year
2023
Related Publications
Eye Health & Vision
- Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
- Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa
- Melanopsin and rod–cone photoreceptors play different roles in mediating pupillary light responses during exposure to continuous light in humans
- Characteristic patterns of dendritic remodeling in early-stage glaucoma: evidence from genetically identified retinal ganglion cell types
- Intrinsically photosensitive melanopsin retinal ganglion cell contributions to the pupillary light reflex and circadian rhythm