Summary
This study explores the presence and colocalization of vesicular zinc (via ZnT3) with ipRGCs, the specialized photoreceptors responsible for conveying light information to the circadian clock. Understanding zinc's potential modulatory role in ipRGC function could have downstream implications for how light signals are processed and translated into circadian and sleep-wake regulation.
Key Findings
- ZnT3 (a vesicular zinc transporter) was found to colocalize with a subset of ipRGCs, suggesting vesicular zinc may play a functional role in these circadian photoreceptors.
- Some ZnT3-negative retinal ganglion cells were identified as ipRGCs, indicating heterogeneity in zinc expression among ipRGC subtypes.
Categories
The Science of Light: Examines zinc transporter ZnT3 colocalization with intrinsically photosensitive retinal ganglion cells (ipRGCs), relevant to photoreceptor biology and circadian phototransduction.
Sleep & Circadian Health: Investigates zinc's role in the circadian system, with implications for understanding light-driven circadian entrainment pathways.
Author(s)
M Moshirpour, AS Nakashima, N Sehn, VM Smith
Publication Year
2020
Number of Citations
5
Related Publications
The Science of Light
- Phototransduction by retinal ganglion cells that set the circadian clock
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- Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
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Sleep & Circadian Health
- Phototransduction by retinal ganglion cells that set the circadian clock
- The mammalian circadian timing system: organization and coordination of central and peripheral clocks
- The twoāprocess model of sleep regulation: a reappraisal
- Melanopsin is required for non-image-forming photic responses in blind mice
- Strange vision: ganglion cells as circadian photoreceptors