Summary
This study investigates how elevated intracellular calcium (via ATXII) affects the circadian clock protein BMAL1, with calcineurin playing a regulatory role in its phosphorylation and cellular localisation. While focused on cardiac arrhythmia biology, findings on calcium-mediated disruption of molecular circadian rhythmicity have indirect relevance to understanding how physiological stressors can dysregulate circadian clock function.
Categories
The Science of Light: Examines molecular circadian clock mechanisms (BMAL1 expression, phosphorylation, localisation) and calcium signalling pathways relevant to circadian rhythm biology.
Author(s)
A Siakalli
Publication Year
2020
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