Summary
This research demonstrates that the liver circadian clock and feeding rhythm together are sufficient to drive temporal carbohydrate homeostasis, while lipid and redox metabolism require cross-talk with the skeletal muscle clock. For lighting and healthcare professionals, this underscores the importance of aligning both light exposure and meal timing to support metabolic health, as circadian disruption through either pathway can impair distinct metabolic functions.
Key Findings
- The cooperative action of BMAL1 and transcription factor CEBPB regulates daily liver metabolic transcriptional programs.
- Liver clock combined with feeding rhythm is sufficient to maintain temporal carbohydrate homeostasis, but lipid and redox metabolic rhythms require additional cross-talk with the skeletal muscle clock.
- Peripheral clock cross-talk between liver and skeletal muscle is required for full metabolic circadian regulation, highlighting that no single tissue clock is sufficient for complete metabolic homeostasis.
Categories
Sleep & Circadian Health: Examines how mammalian circadian clocks regulate daily metabolic homeostasis through tissue-specific clock interactions and feeding timing.
The Science of Light: Provides mechanistic insight into circadian clock function relevant to understanding entrainment and the biological basis of light-driven circadian regulation.
Author(s)
E Challet
Related Publications
Sleep & Circadian Health
- Phototransduction by retinal ganglion cells that set the circadian clock
- The mammalian circadian timing system: organization and coordination of central and peripheral clocks
- The twoāprocess model of sleep regulation: a reappraisal
- Melanopsin is required for non-image-forming photic responses in blind mice
- Strange vision: ganglion cells as circadian photoreceptors
The Science of Light
- Phototransduction by retinal ganglion cells that set the circadian clock
- Color appearance models
- The mammalian circadian timing system: organization and coordination of central and peripheral clocks
- Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
- Melanopsin is required for non-image-forming photic responses in blind mice