Summary
This study characterizes retinal changes in MTHFR-deficient mice with mild hyperhomocysteinemia, including impacts on intrinsically photosensitive retinal ganglion cells (ipRGCs) that contain melanopsin and drive non-image-forming light responses. Damage to ipRGCs could have downstream implications for circadian photoentrainment and pupillary light reflex function in conditions of elevated homocysteine.
Categories
Eye Health & Vision: Examines retinal ganglion cell health including intrinsically photosensitive RGCs in a mouse model of hyperhomocysteinemia.
The Science of Light: Discusses melanopsin-containing ipRGCs and their role in pupillary light reflex, relevant to photoreceptor biology.
Author(s)
S Markand
Publication Year
2015
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