Ultrastructure of synaptic connectivity within sub-regions of the SCN revealed by genetically encoded EM tag and SBEM
Summary:
The paper discusses the synaptic connectivity within the suprachiasmatic nucleus (SCN) of the hypothalamus in the vertebrate brain, focusing on the inputs from melanopsin-expressing retinal ganglion cells (mRGC) and how they contribute to the regulation of the circadian clock.
Categories
- Cognitive function and memory: The paper explores the synaptic connections within the SCN, a part of the brain that plays a crucial role in the regulation of circadian rhythms, which are important for cognitive function and memory.
- Sleep and insomnia: The study's focus on the SCN, which regulates circadian rhythms, is relevant to sleep and insomnia as disruptions in these rhythms can lead to sleep disorders.
- Hormone regulation: The paper discusses the role of the SCN in regulating circadian rhythms, which involves the release of various hormones.
- Lighting Design Considerations: The study examines how the SCN receives photic information from mRGCs, which could have implications for lighting design that takes into account the impact of light on circadian rhythms.
- Aging: The paper mentions that the findings could provide a framework to understand the age-dependent deterioration of circadian organization.
Author(s)
H Calligaro, A Shoghi, X Chen, KY Kim, YH Liu, B Khov
Publication Year:
2022
Number of Citations:
0
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