Ultrastructure of synaptic connectivity within sub-regions of the SCN revealed by genetically encoded EM tag and SBEM



The paper discusses the synaptic connectivity within the suprachiasmatic nucleus (SCN) of the hypothalamus in the vertebrate brain, focusing on the inputs from melanopsin-expressing retinal ganglion cells (mRGC) and how they contribute to the regulation of the circadian clock.


  • Cognitive function and memory: The paper explores the synaptic connections within the SCN, a part of the brain that plays a crucial role in the regulation of circadian rhythms, which are important for cognitive function and memory.
  • Sleep and insomnia: The study's focus on the SCN, which regulates circadian rhythms, is relevant to sleep and insomnia as disruptions in these rhythms can lead to sleep disorders.
  • Hormone regulation: The paper discusses the role of the SCN in regulating circadian rhythms, which involves the release of various hormones.
  • Lighting Design Considerations: The study examines how the SCN receives photic information from mRGCs, which could have implications for lighting design that takes into account the impact of light on circadian rhythms.
  • Aging: The paper mentions that the findings could provide a framework to understand the age-dependent deterioration of circadian organization.


H Calligaro, A Shoghi, X Chen, KY Kim, YH Liu, B Khov
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