The role of the circadian clock in animal models of mood disorders.



This paper discusses the role of the circadian clock in mood disorders, specifically depression and bipolar disorder, and reviews animal models used to investigate the causal connection between circadian rhythms and mood.


  • Depression: The paper discusses the relationship between circadian rhythms and depression, noting that patients with depression often suffer from disturbed sleep/wake cycles and altered rhythms in daily activities.
  • Mood regulation: The paper explores how circadian rhythms may play a role in mood regulation, and how disruptions to these rhythms may contribute to mood disorders.
  • Cognitive function and memory: The paper discusses the role of various genes in circadian rhythms, which are linked to cognitive function and memory.
  • Psychiatric Disorders: The paper discusses the role of circadian rhythms in psychiatric disorders, specifically mood disorders such as depression and bipolar disorder.
  • Sleep and insomnia: The paper discusses how disturbed sleep/wake cycles, a form of insomnia, are often seen in patients with mood disorders, suggesting a link between sleep and these disorders.
  • Lighting Design Considerations: The paper discusses how light is the main external timing cue for circadian rhythms, which are linked to mood disorders.
  • Phototherapy: The paper mentions that therapeutic treatments targeting the circadian clock, such as light exposure, have been developed for mood disorders.


D Landgraf, MJ McCarthy, DK Welsh
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