Illuminating the inner retina of vertebrates: Nonvisual photopigments with novel functions



This paper discusses the role of intrinsically photosensitive retinal ganglion cells (ipRGCs) in vertebrates, their evolution, and their function in non-visual photoreception and regulation of various light-driven non-visual functions.


  • Cognitive function and memory: The paper discusses the role of ipRGCs in transmitting information to the brain, which is relevant to cognitive function.
  • Sleep and insomnia: The paper mentions the role of ipRGCs in regulating sleep and other non-visual functions.
  • Seasonal affective disorder: The paper discusses how alterations in lighting conditions can cause seasonal depression, which is treated with phototherapy.
  • Phototherapy: The paper discusses the use of phototherapy in treating seasonal depression caused by alterations in lighting conditions.
  • Hormone regulation: The paper discusses the role of ipRGCs in the light inhibition of the hormone melatonin.
  • Lighting Design Considerations: The paper discusses how different lighting conditions can affect physiology and behavior, which is relevant to lighting design considerations.
  • Well-being: The paper discusses how light detection and regulation of various non-visual functions by ipRGCs can affect the overall well-being of an individual.


ME Guido
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