Summary
This review explores how E3 ubiquitin ligases control circadian rhythm timing by marking clock proteins for degradation, maintaining the ~24-hour transcription-translation feedback loop. While highly mechanistic, understanding these proteolytic pathways could inform future pharmacological approaches to correct circadian misalignment when light-based interventions are insufficient.
Categories
The Science of Light: Examines molecular mechanisms underlying circadian clock function, specifically how protein degradation via E3 ubiquitin ligases regulates core clock gene oscillations in model organisms.
Author(s)
OHMH Abdalla, B Mascarenhas
Publication Year
2022
Number of Citations
5
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