Summary
This thesis investigates the suprachiasmatic nucleus (SCN) as the master circadian pacemaker using translational switching techniques to probe clock mechanisms. Understanding SCN clockwork is foundational for designing light interventions that effectively entrain human circadian rhythms in clinical and architectural contexts.
Categories
Sleep & Circadian Health: Investigates the SCN molecular clockwork that drives circadian rhythms of physiology and behavior.
The Science of Light: Examines the mechanistic basis of circadian entrainment at the level of the principal circadian pacemaker.
Author(s)
D McManus
Publication Year
2023
Related Publications
Sleep & Circadian Health
- Phototransduction by retinal ganglion cells that set the circadian clock
- The mammalian circadian timing system: organization and coordination of central and peripheral clocks
- The twoāprocess model of sleep regulation: a reappraisal
- Melanopsin is required for non-image-forming photic responses in blind mice
- Strange vision: ganglion cells as circadian photoreceptors
The Science of Light
- Phototransduction by retinal ganglion cells that set the circadian clock
- Color appearance models
- The mammalian circadian timing system: organization and coordination of central and peripheral clocks
- Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
- Melanopsin is required for non-image-forming photic responses in blind mice