The short-day cycle induces intestinal epithelial purine metabolism imbalance and hepatic disfunctions in antibiotic-mediated gut microbiota perturbation mice

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Summary

This study examines how short-day light-dark cycles interact with antibiotic-induced gut microbiota disruption to cause intestinal purine metabolism imbalance and hepatic dysfunction in mice, highlighting the systemic health consequences of altered light exposure. For lighting designers and healthcare practitioners, the findings suggest that insufficient daily light exposure may compound gut-liver axis dysfunction, particularly in patients undergoing antibiotic treatment.

Key Findings

Short-day light cycles combined with antibiotic-mediated gut microbiota perturbation induced measurable imbalances in intestinal epithelial purine metabolism compared to normal light-dark cycle controls.
Hepatic dysfunction markers were elevated in mice exposed to short-day cycles with disrupted microbiota, suggesting circadian light-dark cycle length has direct implications for liver health beyond sleep regulation.
Light-dark cycle manipulation operated through ipRGC-mediated circadian entrainment pathways, linking environmental light directly to gut-liver axis homeostasis.