Summary
This research investigates reprogramming Müller glia to regenerate retinal ganglion cells, including the melanopsin-producing ipRGCs that serve as the primary photoreceptors for non-visual light responses such as circadian entrainment. Successful regeneration of ipRGCs could have profound implications for restoring circadian light sensitivity in patients who have lost these cells due to disease or injury.
Categories
Eye Health & Vision: Examines retinal ganglion cell regeneration including intrinsically photosensitive RGCs (ipRGCs) that express melanopsin, relevant to retinal health and photoreceptor function.
The Science of Light: Discusses melanopsin-expressing ipRGCs and their role in light interaction, directly relevant to photoreceptor biology and the non-visual light sensing system.
Author(s)
W Jenkins
Publication Year
2023
Related Publications
Eye Health & Vision
- Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
- Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa
- Melanopsin and rod–cone photoreceptors play different roles in mediating pupillary light responses during exposure to continuous light in humans
- Characteristic patterns of dendritic remodeling in early-stage glaucoma: evidence from genetically identified retinal ganglion cell types
- Intrinsically photosensitive melanopsin retinal ganglion cell contributions to the pupillary light reflex and circadian rhythm
The Science of Light
- Phototransduction by retinal ganglion cells that set the circadian clock
- Color appearance models
- The mammalian circadian timing system: organization and coordination of central and peripheral clocks
- Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
- Melanopsin is required for non-image-forming photic responses in blind mice