Summary
Multiple sclerosis disrupts circadian rhythmicity through inflammatory and metabolic mechanisms, including changes to the retino-hypothalamic tract that may impair light-based entrainment of the circadian clock. Chronotherapeutic approaches, including time-restricted eating and potentially circadian lighting strategies, may help restore immunological and metabolic rhythms in MS patients.
Key Findings
- MS is associated with disruption of circadian rhythmicity, including clock gene variations and dysregulation of circadian hormones such as melatonin and cortisol.
- Retino-hypothalamic tract changes in MS patients may impair normal light-driven circadian entrainment, suggesting that standard lighting interventions may be less effective without accounting for visual pathway damage.
- Time-restricted eating (TRE) is proposed as a chronotherapeutic strategy to stabilize circadian clocks and potentially counteract MS disease progression, though robust human trial data remain limited.
Categories
Sleep & Circadian Health: Reviews circadian rhythm disruption in MS including clock gene variations, circadian hormones, and retino-hypothalamic tract changes relevant to light-based interventions.
The Science of Light: Discusses retino-hypothalamic tract changes in MS patients that affect circadian entrainment and phototransduction pathways.
Author(s)
O Pivovarova‐Ramich, HG Zimmermann
Publication Year
2023
Number of Citations
5
Related Publications
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The Science of Light
- Phototransduction by retinal ganglion cells that set the circadian clock
- Color appearance models
- The mammalian circadian timing system: organization and coordination of central and peripheral clocks
- Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
- Melanopsin is required for non-image-forming photic responses in blind mice