Summary
This review summarizes mouse models of Alzheimer's disease including transgenic, knock-in, and neuroinflammation-based models, highlighting their utility in studying amyloid and tau pathology. While not directly addressing lighting interventions, the mechanistic insights into AD pathophysiology inform the biological targets that circadian and light-based therapies may aim to modulate.
Categories
Dementia & Elder Care: Reviews animal models of Alzheimer's disease relevant to understanding neurodegeneration and developing therapeutics.
Author(s)
S Kumagai, S Leader, N Miura
Publication Year
2021
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