Summary
This study identifies Satb2 as a molecular marker for direction-selective retinal ganglion cells (DSGCs) in mice and rabbits, but finds it does not mark equivalent cells in macaque primates, suggesting evolutionary divergence of motion-detecting circuits. While primarily basic science, these findings have implications for understanding primate retinal architecture, including circuits relevant to non-image-forming photoreception research.
Key Findings
- Satb2 selectively marks three RGC types in mice: anterior- and posterior-direction On-Off DSGCs, a newly identified Off-DSGC, and an Off-sustained RGC type.
- In rabbits, Satb2 expression is conserved in On-Off DSGCs but expanded to include cells encoding upward and downward motion.
- In macaques, Satb2 is expressed in likely a single RGC type with large, monostratified dendritic arbors morphologically distinct from mouse/rabbit DSGCs, indicating On-Off DSGCs expressing Satb2 are likely absent in primates.
Categories
Eye Health & Vision: Investigates retinal ganglion cell types involved in motion detection across species, with relevance to understanding primate visual circuits and retinal organization.
Author(s)
OS Dhande, BK Stafford, K Franke
Publication Year
2019
Number of Citations
40
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