Summary
This review examines the evolutionary and developmental biology of retinal cells, focusing on photoreception and the molecular mechanisms underlying retinal diversification, including the identification of novel opsin-expressing cell subtypes. Understanding these cellular subtypes and their molecular profiles has implications for future regenerative medicine approaches to treating retinal diseases.
Key Findings
- The homeobox gene Lhx1 plays a role in subdividing the retina into two domains: neural retina and retinal pigmented epithelium
- Novel retinal cell subtypes with photosensory functions were proposed based on the identification of atypical photopigments (opsins) in vertebrates
- The two retinal domains (neural retina and RPE) are identified as fundamental components conserved across diverse eye types, including prototypic planarian eyes
Categories
Eye Health & Vision: Reviews retinal cell evolution, development, and photoreceptor biology with implications for regenerative medicine targeting retinal diseases.
The Science of Light: Discusses atypical photopigments (opsins) and novel retinal cell subtypes with photosensory functions, relevant to understanding photoreception mechanisms.
Author(s)
H Ohuchi
Publication Year
2013
Number of Citations
6
Related Publications
Eye Health & Vision
- Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
- Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa
- Melanopsin and rod–cone photoreceptors play different roles in mediating pupillary light responses during exposure to continuous light in humans
- Characteristic patterns of dendritic remodeling in early-stage glaucoma: evidence from genetically identified retinal ganglion cell types
- Intrinsically photosensitive melanopsin retinal ganglion cell contributions to the pupillary light reflex and circadian rhythm
The Science of Light
- Phototransduction by retinal ganglion cells that set the circadian clock
- Color appearance models
- The mammalian circadian timing system: organization and coordination of central and peripheral clocks
- Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
- Melanopsin is required for non-image-forming photic responses in blind mice