Summary
This study uses multi-omics analysis to explore how circadian clock disruption at the molecular level interacts with cancer pathogenesis, highlighting the role of ipRGCs and melanopsin in conveying light signals to the central pacemaker. For lighting designers and healthcare professionals, the findings underscore the importance of maintaining robust light-dark cycles to support circadian integrity and potentially reduce cancer-related risks.
Key Findings
- Melanopsin-producing ipRGCs are identified as the primary transducers of light signals to the central circadian pacemaker (suprachiasmatic nucleus).
- Multi-omics integration reveals molecular crosstalk between circadian clock gene dysregulation and cancer pathogenesis pathways, suggesting circadian disruption as a cancer risk factor.
Categories
Sleep & Circadian Health: Examines circadian clock mechanisms and their molecular underpinnings relevant to light entrainment and circadian regulation.
The Science of Light: Describes melanopsin-producing ipRGCs as light signal transducers to the central pacemaker, informing photoreceptor biology.
Author(s)
A PĂ©rez-Villa, G EcheverrĂa-GarcĂ©s
Publication Year
2023
Number of Citations
1
Related Publications
Sleep & Circadian Health
- Phototransduction by retinal ganglion cells that set the circadian clock
- The mammalian circadian timing system: organization and coordination of central and peripheral clocks
- The twoâprocess model of sleep regulation: a reappraisal
- Melanopsin is required for non-image-forming photic responses in blind mice
- Strange vision: ganglion cells as circadian photoreceptors
The Science of Light
- Phototransduction by retinal ganglion cells that set the circadian clock
- Color appearance models
- The mammalian circadian timing system: organization and coordination of central and peripheral clocks
- Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
- Melanopsin is required for non-image-forming photic responses in blind mice