Summary
This study compares five promoters for driving transgene expression in retinal ganglion cells using AAV2 vectors, aiming to optimize gene therapy approaches for retinal diseases. The findings have implications for developing treatments targeting retinal ganglion cell degeneration in conditions such as glaucoma and optic neuropathy.
Categories
Eye Health & Vision: This paper investigates AAV-mediated gene delivery to retinal ganglion cells, which are critical for vision and are implicated in glaucoma and other optic neuropathies.
Author(s)
B Nieuwenhuis, E Laperrousaz, JR Tribble
Publication Year
2023
Number of Citations
11
Related Publications
Eye Health & Vision
- Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
- Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa
- Melanopsin and rod–cone photoreceptors play different roles in mediating pupillary light responses during exposure to continuous light in humans
- Characteristic patterns of dendritic remodeling in early-stage glaucoma: evidence from genetically identified retinal ganglion cell types
- Intrinsically photosensitive melanopsin retinal ganglion cell contributions to the pupillary light reflex and circadian rhythm