Summary
This study examines how glucocorticoids regulate molecular clock gene Per1 expression and dendritic spine density in the ventromedial prefrontal cortex across different times of day in mice. Adrenalectomy reduced Per1 rhythmicity, while dendritic spine density peaked during the active phase, suggesting circadian and glucocorticoid co-regulation of prefrontal cortex plasticity.
Key Findings
- Glucocorticoids are required for normal Per1 clock gene rhythmicity in the infralimbic and prelimbic prefrontal cortex.
- Dendritic spine density in the vmPFC peaks at ZT16 (active phase) and troughs at ZT3, indicating time-of-day structural plasticity.
- Changes in spine density were specific to long thin and stubby spine subtypes.
Categories
Sleep & Circadian Health: Investigates molecular clock rhythmicity and circadian regulation in the prefrontal cortex
The Science of Light: Examines how light/dark phase timing affects neural structure and glucocorticoid-driven clock entrainment
Author(s)
AM Miller
Publication Year
2022
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The Science of Light
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