Summary
This study evaluates clock gene expression in peripheral blood of sepsis patients in critical care, finding significant alterations compared to controls. These findings suggest that circadian molecular disruption is a measurable feature of critical illness, with implications for timing of interventions and light-based circadian support in the ICU.
Key Findings
- Significant alteration in clock gene expression was observed in peripheral blood of sepsis patients compared to non-sepsis critical care patients.
- Clock gene disruption in sepsis patients was greater than that observed in other critically ill patient groups (abstract truncated; full quantitative data not available).
Categories
ICU & Critical Care: Examines clock gene expression disruption in critically ill sepsis patients, directly relevant to circadian disruption in the ICU setting.
The Science of Light: Investigates molecular circadian clock mechanisms (clock gene expression) providing foundational science for understanding circadian disruption in critical care.
Author(s)
C Acuña Fernández
Publication Year
2020
Related Publications
ICU & Critical Care
- The effect of light on critical illness
- The evening light environment in hospitals can be designed to produce less disruptive effects on the circadian system and improve sleep
- Circadian Lighting Was Associated with a Reduction in the Number of Hospitalized Patients Experiencing Falls: A Retrospective Observational Study
- Effect of Dynamic Light at the Coronary Care Unit on the Length of Hospital Stay and Development of Delirium
- Use of Lung Ultrasound in the New Definitions of Acute Respiratory Distress Syndrome Increases the Occurrence Rate of Acute Respiratory Distress Syndrome
The Science of Light
- Phototransduction by retinal ganglion cells that set the circadian clock
- Color appearance models
- The mammalian circadian timing system: organization and coordination of central and peripheral clocks
- Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
- Melanopsin is required for non-image-forming photic responses in blind mice