Summary
MS patients with prior optic neuritis show measurably impaired pupillary light responses compared to healthy controls, particularly in contraction amplitude and latency, while MS patients without optic neuritis show no significant difference from healthy subjects. These findings are relevant for lighting designers and clinicians working with MS populations, as compromised pupillary responses may affect light adaptation and could inform individualized lighting recommendations.
Key Findings
- MS patients with prior optic neuritis (MSON) had significantly reduced contraction amplitude compared to healthy controls (40.71 ± 6.73% vs. 45.22 ± 3.29%)
- MSON patients showed prolonged contraction latency compared to healthy controls (0.35 ± 0.13 s vs. 0.26 ± 0.05 s)
- MS patients without optic neuritis did not significantly differ from healthy controls in any pupillary parameter (p > 0.05)
- Abnormal time to recover 75% of initial pupil diameter was found in 9% of MS subjects and 12% of MSON subjects
Categories
Eye Health & Vision: Examines pupillary light response abnormalities in multiple sclerosis patients, particularly those with optic neuritis history.
The Science of Light: Measures specific pupillary response parameters (latency, amplitude, velocity) relevant to understanding ipRGC and afferent visual pathway function in disease states.
Author(s)
A Gil-Casas, DP Piñero, A Molina-MartÃn
Publication Year
2023
Related Publications
Eye Health & Vision
- Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
- Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa
- Melanopsin and rod–cone photoreceptors play different roles in mediating pupillary light responses during exposure to continuous light in humans
- Characteristic patterns of dendritic remodeling in early-stage glaucoma: evidence from genetically identified retinal ganglion cell types
- Intrinsically photosensitive melanopsin retinal ganglion cell contributions to the pupillary light reflex and circadian rhythm
The Science of Light
- Phototransduction by retinal ganglion cells that set the circadian clock
- Color appearance models
- The mammalian circadian timing system: organization and coordination of central and peripheral clocks
- Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
- Melanopsin is required for non-image-forming photic responses in blind mice