Summary
This research examines how melanopsin-containing retinal ganglion cells (ipRGCs) develop, including changes in dendritic stratification and cell distribution, with rods and cones potentially regulating normal developmental cell death of ipRGCs. Understanding ipRGC maturation has implications for designing appropriate lighting environments for neonates and preterm infants whose circadian photoreception systems are still developing.
Categories
The Science of Light: Investigates the developmental biology of melanopsin-containing ipRGCs, their dendritic stratification, cell distribution, and relationship with rod/cone photoreceptors.
Neonatal Care: Examines developmental regulation of ipRGCs with implications for circadian function maturation in early life stages.
Author(s)
L Ruggiero
Publication Year
2008
Related Publications
The Science of Light
- Phototransduction by retinal ganglion cells that set the circadian clock
- Color appearance models
- The mammalian circadian timing system: organization and coordination of central and peripheral clocks
- Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
- Melanopsin is required for non-image-forming photic responses in blind mice
Neonatal Care
- Retinal waves modulate an intraretinal circuit of intrinsically photosensitive retinal ganglion cells
- No loss of melanopsin-expressing ganglion cells detected during postnatal development of the mouse retina
- The retinal basis of light aversion in neonatal mice
- Neuronal Bmal1 regulates retinal angiogenesis and neovascularization in mice
- Mechanisms of Cardiovascular Changes of Phototherapy in Newborns with Hyperbilirubinemia.