Summary
This thesis investigates how the circadian system, driven by ipRGC light input via the retinohypothalamic tract to the SCN, becomes disrupted in neurodegenerative and affective diseases, and how peripheral clocks are affected under constant light conditions. Understanding these pathways has practical implications for designing circadian-supportive lighting interventions in clinical and care environments to improve patient outcomes.
Categories
Sleep & Circadian Health: Examines circadian system synchronization including light-dark cycles, SCN entrainment, and peripheral clocks under constant light conditions.
Dementia & Elder Care: Investigates circadian disruption in neurodegenerative diseases such as Alzheimer's and Parkinson's.
Mood & Mental Wellness: Addresses circadian involvement in affective disorders and mood-related conditions.
Author(s)
K Weissová
Publication Year
2020
Related Publications
Sleep & Circadian Health
- Phototransduction by retinal ganglion cells that set the circadian clock
- The mammalian circadian timing system: organization and coordination of central and peripheral clocks
- The two‐process model of sleep regulation: a reappraisal
- Melanopsin is required for non-image-forming photic responses in blind mice
- Strange vision: ganglion cells as circadian photoreceptors
Dementia & Elder Care
- Light therapy and Alzheimer's disease and related dementia: past, present, and future
- New strategies for neuroprotection in glaucoma, a disease that affects the central nervous system
- Sleep and circadian rhythms in Parkinson's disease and preclinical models
- Chronobioengineering indoor lighting to enhance facilities for ageing and Alzheimer's disorder
- The clock is ticking. Ageing of the circadian system: from physiology to cell cycle
Mood & Mental Wellness
- The two‐process model of sleep regulation: a reappraisal
- Protecting the melatonin rhythm through circadian healthy light exposure
- Effects of artificial dawn and morning blue light on daytime cognitive performance, well-being, cortisol and melatonin levels
- Light therapy and Alzheimer's disease and related dementia: past, present, and future
- The role of daylight for humans: gaps in current knowledge