Summary
This study evaluated the safety and therapeutic effects of human bone marrow-derived mononuclear stem cell transplants in two rat models of inherited photoreceptor degeneration, finding no photoreceptor neuroprotection but a notable reduction in retinal gliosis. While not directly applicable to lighting design, the findings are relevant to understanding retinal health and disease progression in conditions that may influence light sensitivity and visual function.
Key Findings
- Transplanted CD45+ cells survived up to 15 days post-injection, forming clusters in the vitreous or a 2–3-cell-thick layer in the subretinal space depending on injection route.
- Injected eyes showed decreased GFAP immunoreactivity (indicating reduced retinal gliosis) in both P23H-1 and RCS rat models, without a corresponding increase in photoreceptor survival.
- No local adverse effects were observed from intravitreal or subretinal hBM-MSC injections across all time points (7, 15, 30, and 60 days).
- No significant reduction in microglial cell numbers was detected in injected eyes compared to controls.
Categories
Eye Health & Vision: Investigates stem cell transplantation effects on retinal degeneration, gliosis, and photoreceptor survival in animal models of inherited blindness.
Author(s)
J Di Pierdomenico, D GarcÃa-Ayuso
Publication Year
2020
Number of Citations
15
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