Summary
This study examines how circadian disruption and prenatal immune activation interact at behavioral and cellular levels in mice, with implications for understanding neurodevelopmental and circadian system vulnerabilities. The involvement of ipRGCs and the SCN highlights pathways through which light-dark cycle disruption may affect brain function beyond the central clock.
Key Findings
- Circadian disruption combined with prenatal immune activation produced distinct behavioral and cellular changes in mice compared to either condition alone.
- ipRGCs were identified as mediating light input to the SCN and other brain areas, suggesting that circadian disruption effects may extend to regions beyond the primary circadian pacemaker.
Categories
Sleep & Circadian Health: Investigates behavioral and cellular responses to circadian disruption in a mouse model.
The Science of Light: Involves ipRGC and SCN biology in the context of circadian entrainment and disruption.
Author(s)
TC Delorme, W Ozell-Landry, N Cermakian
Publication Year
2023
Number of Citations
1
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