The regulation of stress-induced changes in the expression of the circadian clock protein PERIOD1, in the mammalian limbic forebrain and hypothalamus


Abstract

Summary:

This paper discusses the effects of stress on the expression of the circadian clock protein PERIOD1 in the mammalian forebrain and hypothalamus, and how this could lead to disturbances in circadian physiology and behavior.
Categories

Categories

  • Cognitive function and memory: The paper discusses how stress can alter the expression of the circadian clock protein PERIOD1 in the mammalian forebrain and hypothalamus, which could potentially affect cognitive function and memory.
  • Hormone regulation: The paper explores the role of glucocorticoids and glucocorticoid receptors in the modulation of stress-induced PERIOD1, a protein involved in hormone regulation.
  • Phototherapy: The paper mentions that the light-sensitive master pacemaker, the suprachiasmatic nucleus (SCN), remained immune to the effects of all stress manipulations, which could have implications for phototherapy treatments.
  • Shift work: The paper discusses how the time of day and modality of stress exposure are vital factors that influence PERIOD1 activity, which could have implications for shift workers.
  • Well-being: The paper suggests that stress-induced changes in PERIOD1 expression could lead to disturbances in circadian physiology and behavior, potentially affecting overall well-being.
Authors

Author(s)

S Al-Safadi
Publication Date

Publication Year:

2014
Citations

Number of Citations:

0
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