Summary
Peripapillary retinal nerve fiber layer (pRNFL) and macular thinning were identified as candidate markers for monitoring disease severity in progressive supranuclear palsy (PSP). Macular thinning may also serve as an in vivo indicator of nigrostriatal dopaminergic cell degeneration, offering a non-invasive window into neurodegeneration.
Key Findings
- pRNFL and macular thinning correlated with disease severity in PSP patients.
- Macular thinning was identified as a potential in vivo marker of nigrostriatal dopaminergic cell degeneration in PSP.
Categories
Eye Health & Vision: Retinal thinning (pRNFL and macular) is examined as a biomarker of disease severity in progressive supranuclear palsy, relevant to ocular health monitoring.
Dementia & Elder Care: PSP is a neurodegenerative condition, and retinal thinning is linked to nigrostriatal dopaminergic cell degeneration, relevant to neurodegeneration monitoring in aging populations.
Author(s)
Y Chen, H Wang, B Wang, W Li, P Ye, W Xu
Publication Year
2023
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