Metabolic and immune effects of Bmal1 deletion in neutrophils
Summary:
The paper investigates the influence of the neutrophil circadian clock on body weight regulation and metaflammation under high-fat diet feeding, finding that absence of the circadian clock in neutrophils leads to lower body weight and decreased adiposity.
Categories
- Obesity and Weight Management: The paper explores the role of the neutrophil circadian clock in body weight regulation, finding that its absence leads to lower body weight and decreased adiposity under high-fat diet feeding.
- Diabetes and metabolic syndrome: The paper discusses the role of the neutrophil circadian clock in metabolic state regulation, finding that its absence leads to improved glucose tolerance and insulin sensitivity under high-fat diet feeding.
- Immune system function and health: The paper investigates the role of the neutrophil circadian clock in metaflammation, a type of chronic low-grade inflammation in adipose tissue and other metabolic organs.
- Shift work: The paper indirectly references shift work as a factor that often causes circadian disruption, which is a risk factor for obesity and metabolic disease.
Author(s)
B Leinweber
Publication Year:
2022
Number of Citations:
0
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