Inputs and Outputs of the Mammalian Circadian Clock
Summary:
This paper reviews the current understanding of the synaptic and non-synaptic inputs onto and outputs from the suprachiasmatic nucleus (SCN), proposing that a more complete description of SCN connectivity is needed to better explain how rhythms in nearly all behaviors and physiological processes are generated and to determine how these rhythms are disrupted by disease or lifestyle.
Categories
- Cognitive function and memory: The paper discusses the role of the suprachiasmatic nucleus (SCN) in controlling circadian rhythms in nearly all behaviors and physiological processes, which includes cognitive function and memory.
- Sleep and insomnia: The paper explores the role of the SCN in controlling circadian rhythms, which are crucial for regulating sleep patterns.
- Hormone regulation: The paper discusses the role of the SCN in receiving and integrating hormonal signals from the periphery.
- Lighting Design Considerations: The paper discusses the role of light in activating intrinsically-photosensitive retinal ganglion cells (ipRGCs) which project through the retinohypothalamic tract (RHT) to the SCN, influencing circadian rhythms.
- Well-being: The paper discusses the potential negative impact on human health when the circuits linking the outside world to the SCN and the SCN to rhythmic outputs are disrupted.
Author(s)
AN Starnes, JR Jones
Publication Year:
2023
Number of Citations:
4
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