Combined single-cell RNA-seq profiling and enhancer editing reveals critical spatiotemporal controls over thalamic nuclei formation in the murine embryo
Summary:
The paper investigates the molecular mechanisms regulating the formation of thalamic nuclei, revealing that the complex architecture of the thalamus is established early during embryonic brain development through the coordinated action of four cell differentiation lineages.
Categories
- Cognitive function and memory: The paper discusses the role of the thalamus in attention and memory, and investigates the molecular mechanisms that regulate its formation.
- Education and learning: The paper contributes to the understanding of brain development, specifically the formation of thalamic nuclei, which is relevant to learning and cognitive function.
- Aging: The paper's focus on the development of the thalamus, a part of the brain that plays a crucial role in cognitive function and memory, is relevant to aging as these functions can decline with age.
Author(s)
KW Govek, S Chen, P Sgourdou, Y Yao, S Woodhouse
Publication Year:
2022
Number of Citations:
1
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