Summary
This theoretical work proposes a model in which melatonin inhibits proteasomal degradation of key clock proteins (CRY, PER, BMAL1) in the SCN, thereby modulating circadian timing and photoperiodic responses. The model suggests that proteasome inhibitors like bortezomib could mimic melatonin's effects on circadian rhythms, with potential implications for chronotherapeutic interventions using light and melatonin.
Categories
Sleep & Circadian Health: Examines the molecular mechanisms by which melatonin and the proteasome/deubiquitinase system (USP2) regulate circadian clock gene expression in the SCN.
The Science of Light: Explores how circadian light responses are modulated through post-translational regulation of clock proteins, relevant to understanding phototransduction downstream effects.
Author(s)
S Srikanta
Publication Year
2023
Related Publications
Sleep & Circadian Health
- Phototransduction by retinal ganglion cells that set the circadian clock
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The Science of Light
- Phototransduction by retinal ganglion cells that set the circadian clock
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- The mammalian circadian timing system: organization and coordination of central and peripheral clocks
- Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
- Melanopsin is required for non-image-forming photic responses in blind mice