The p75 neurotrophin receptor is required for the survival of neuronal progenitors and normal formation of the basal forebrain, striatum, thalamus and neocortex
Summary:
This paper discusses the role of the p75 neurotrophin receptor (p75 NTR) in the development of the nervous system, and how its absence can lead to increased apoptosis of progenitor cells, reduced cortical pyramidal neurons, interneurons, cholinergic basal forebrain neurons and striatal neurons, and impaired thalamic midline fusion.
Categories
- Cognitive function and memory: The paper discusses how the absence of p75 NTR can lead to reduced cortical pyramidal neurons and interneurons, which are crucial for cognitive function and memory.
- Neuroscience: The paper extensively discusses the role of p75 NTR in the development of the nervous system, and how its absence can lead to various neurological abnormalities.
Author(s)
S Meier, F Alfonsi, ND Kurniawan, MR Milne
Publication Year:
2019
Number of Citations:
23
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