Summary
This paper explores how circadian disruption interacts with prenatal immune activation to influence neurodevelopmental disorders via the microbiota-gut-brain axis, with relevance to conditions like autism and schizophrenia. While not directly a lighting study, the findings underscore the importance of maintaining stable light-dark cycles during pregnancy and early life to support microbiome health and proper neurodevelopment.
Key Findings
- Circadian disruption is identified as a factor that can interact with prenatal immune activation to influence neurodevelopmental outcomes.
- The microbiota-gut-brain axis communicates via immune system, tryptophan metabolism, vagus nerve, and enteric nervous system, implicating microbial metabolites (short-chain fatty acids, branched chain amino acids, peptidoglycans).
- Early-life factors including infection, birth mode, antibiotics, nutrition, environmental stressors, and genetics influence microbiota composition, with microbial diversity diminishing with aging.
- Animal models have linked gut microbiota regulation to fundamental neural processes including neurogenesis and myelination via microglial activation.
Categories
Sleep & Circadian Health: Examines circadian disruption as a variable interacting with prenatal immune activation in neurodevelopmental outcomes.
Mood & Mental Wellness: Discusses implications for psychiatric and neurodevelopmental disorders including autism, schizophrenia, and anxiety through the microbiota-gut-brain axis.
Author(s)
T Delorme
Publication Year
2023
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