Summary
This study investigates how endothelin-1 modulates circadian clock genes (Per1, Cry1b, Clock) and melanopsin in embryonic zebrafish (Danio rerio) cells. It explores the interplay between vasoactive peptides and the molecular circadian clock machinery, including peripheral oscillator synchronization.
Key Findings
- Endothelin-1 can modulate expression of core circadian clock genes Per1, Cry1b, and Clock in zebrafish embryonic cells
- Melanopsin, expressed in intrinsically photosensitive retinal ganglion cells, is also subject to regulation by endothelin-1 signaling
- Peripheral oscillators in zebrafish can be directly entrained by light, unlike mammals where SCN coordinates peripheral clock resetting
Categories
The Science of Light: Investigates melanopsin and clock gene regulation by endothelin-1, directly relevant to circadian photoreception mechanisms
Sleep & Circadian Health: Examines core circadian clock genes (Per1, Cry1b, Clock) and their modulation in a model organism
Author(s)
FP Farhat
Publication Year
2007
Related Publications
The Science of Light
- Phototransduction by retinal ganglion cells that set the circadian clock
- Color appearance models
- The mammalian circadian timing system: organization and coordination of central and peripheral clocks
- Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
- Melanopsin is required for non-image-forming photic responses in blind mice
Sleep & Circadian Health
- Phototransduction by retinal ganglion cells that set the circadian clock
- The mammalian circadian timing system: organization and coordination of central and peripheral clocks
- The two‐process model of sleep regulation: a reappraisal
- Melanopsin is required for non-image-forming photic responses in blind mice
- Strange vision: ganglion cells as circadian photoreceptors