Summary
This thesis investigates oxidative stress effects (UVA and endogenous) on the human cornea, including mitochondrial DNA deletions, while also touching on ipRGC signaling and its downstream hormonal effects. For lighting designers, it highlights potential retinal and corneal risks from UV exposure and the biological importance of ipRGC-mediated light signals.
Categories
Eye Health & Vision: Discusses intrinsically photosensitive retinal ganglion cells (ipRGCs) and oxidative stress effects on the human cornea.
The Science of Light: References ipRGCs and their role in hormonal signaling cascades relevant to photoreceptor biology.
Author(s)
SP Gendron
Publication Year
2016
Related Publications
Eye Health & Vision
- Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
- Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa
- Melanopsin and rod–cone photoreceptors play different roles in mediating pupillary light responses during exposure to continuous light in humans
- Characteristic patterns of dendritic remodeling in early-stage glaucoma: evidence from genetically identified retinal ganglion cell types
- Intrinsically photosensitive melanopsin retinal ganglion cell contributions to the pupillary light reflex and circadian rhythm
The Science of Light
- Phototransduction by retinal ganglion cells that set the circadian clock
- Color appearance models
- The mammalian circadian timing system: organization and coordination of central and peripheral clocks
- Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
- Melanopsin is required for non-image-forming photic responses in blind mice