Summary
This paper investigates the varied signaling pathways used by ipRGC subtypes, including the unexpected finding that some ipRGCs release inhibitory neurotransmitters, challenging the conventional model of light signaling. Understanding these diverse mechanisms has implications for how lighting design can be optimized to target specific non-visual and circadian pathways.
Key Findings
- ipRGCs employ diverse signaling mechanisms beyond the standard model of light information transmission
- A subpopulation of ipRGCs releases inhibitory neurotransmitters, contradicting the prevailing excitatory-only signaling model for these cells
Categories
The Science of Light: Examines the diverse signaling mechanisms of intrinsically photosensitive retinal ganglion cells (ipRGCs), directly relevant to understanding how light information is transduced and transmitted.
Author(s)
T Sonoda
Publication Year
2020
Related Publications
The Science of Light
- Phototransduction by retinal ganglion cells that set the circadian clock
- Color appearance models
- The mammalian circadian timing system: organization and coordination of central and peripheral clocks
- Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
- Melanopsin is required for non-image-forming photic responses in blind mice