Summary
This study identifies TFAP2B as a critical transcription factor in the nervous system for regulating NREM sleep and potentially ipRGC development, which are the retinal cells responsible for circadian light entrainment. Understanding genetic regulators of ipRGC development and sleep architecture may inform approaches to treating circadian rhythm disorders and sleep deficiencies.
Key Findings
- TFAP2B deficits are associated with impairments in light entrainment, suggesting a role in ipRGC development or function.
- TFAP2B plays a crucial role in the nervous system specifically for regulating NREM sleep stages.
Categories
Sleep & Circadian Health: Investigates TFAP2B transcription factor's role in regulating NREM sleep and light entrainment, with implications for circadian rhythm mechanisms.
The Science of Light: Examines TFAP2B's potential role in ipRGC development, which are the key photoreceptors mediating non-visual light responses including circadian entrainment.
Author(s)
A Nakai, M Kashiwagi, T Fujiyama, K Iwasaki, A Hirano
Publication Year
2023
Related Publications
Sleep & Circadian Health
- Phototransduction by retinal ganglion cells that set the circadian clock
- The mammalian circadian timing system: organization and coordination of central and peripheral clocks
- The twoāprocess model of sleep regulation: a reappraisal
- Melanopsin is required for non-image-forming photic responses in blind mice
- Strange vision: ganglion cells as circadian photoreceptors
The Science of Light
- Phototransduction by retinal ganglion cells that set the circadian clock
- Color appearance models
- The mammalian circadian timing system: organization and coordination of central and peripheral clocks
- Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
- Melanopsin is required for non-image-forming photic responses in blind mice