Summary
This study investigates how the RNA-binding protein Fxr1 is regulated by the circadian clock and how it in turn regulates core clock genes through the transcription-translation feedback loop. Findings reveal bidirectional interactions between Fxr1 and circadian machinery, with implications for mood and psychiatric disorders associated with circadian disruption.
Key Findings
- Fxr1 mRNA oscillations are lost in clockΔ19 mice, confirming circadian regulation of Fxr1 expression.
- CLOCK/BMAL1 and NPAS2/BMAL1 heterodimers regulate Fxr1 via e-boxes in its promoter, with repression by GSK3β.
- Fxr1 is required for rhythmic oscillation of several circadian genes by binding to their 3'UTR and coding sequences.
Categories
The Science of Light: Investigates molecular mechanisms of circadian clock regulation via RNA-binding protein Fxr1
Mood & Mental Wellness: Fxr1 is linked to mood disorders, schizophrenia, and bipolar disorder, which involve disrupted circadian rhythms
Author(s)
T Soares Silva
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