Summary
This study examines calcium signaling in ganglion cell layer neurons in the rd1 mouse model of retinal degeneration, focusing on P2X7 purinoreceptor-mediated pore formation. Understanding these mechanisms has implications for preserving retinal function and potentially protecting melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs) that are critical for circadian light entrainment.
Categories
Eye Health & Vision: Investigates calcium dynamics and purinoreceptor activation in retinal ganglion cells in a model of inherited retinal degeneration, relevant to photoreceptor damage and retinal health.
The Science of Light: Retinal ganglion cell biology and degeneration mechanisms are relevant to understanding photoreceptor function and the downstream effects on light-sensitive cells including ipRGCs.
Author(s)
J Carr
Publication Year
2020
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